Atletico had won their previous eight games at Wanda Metropolitano and they had a ninth straight home victory wrapped up by half-time after Antoine Griezmann doubled their lead.
Sporting will aim to overturn the deficit without suspended pair Fabio Coentrao and Bas Dost after they were booked in a frustrating second half for the visitors.
In a tie between two sides that dropped down from the Champions League, Atletico underlined why they are the favourites to win the Europa League for a third time.
1 minute , Diego Costa laid the ball off to Koke (Atl. Madrid), who shot from close range into the bottom right corner, leaving the goalkeeper helpless.
And Antoine Griezmann added a second after taking advantage of another Sporting error.